Functional, Integrated, NextCure Discovery in Immuno-Oncology (FIND-IO^TM) Technology

Our FIND-IO platform uses proprietary approaches to functionally assess immune pathways in both primary immune cells and established cell lines from immune lineages, including T cell subsets, monocytes, macrophage subpopulations, dendritic cells, cancer cell lines, and cells isolated from diseased patients. This platform allows us to identify proteins that can be targeted with novel immunomedicines to repair and maintain anti-tumor immunity.

NextCure is addressing the major challenges in supplying next generation, novel targets to address limited treatment options for patients that do not respond to standard treatments or existing immune therapies. NextCure is utilizing FIND-IO^TM technology to “functionally” identify targets that can impact immune responses.

FIND-IO^TM technology is focused on identifying novel cell surface molecular interactions that drive functional immune responses in the tumor microenvironment and other disease sites. We have developed proprietary approaches to functionally assess immune pathways in primary immune cells from healthy donors and patients with various diseases and established cell lines from immune and non-immune cell lineages including T cell subsets, monocytes, macrophage subpopulations and cancer cell lines.

With our current focus in immuno oncology, we have identified several positive and negative immune regulators of myeloid cells and T cells. From these discoveries, we are developing therapeutics that can intervene to modulate interactions of immune cells within the tumor microenvironment to restore anti-tumor activity.

NextCure is leveraging and applying its current FIND-IO^TM technology to functional screening approaches for the identification of novel targets from multiple therapeutic areas, including autoimmunity and neurology, enabling next generation immunotherapeutics to fields beyond oncology with significant unmet medical needs to sustain the growth of the company.