Research and Translation
Harnessing an individual’s own immune system is emerging as a key strategy in disease treatment. Cancer and other diseased cells have developed sophisticated mechanisms to evade or modulate immunological responses.  NextCure has developed a large repertoire of function-based screening and translational methods to develop therapeutics that improve immune function.  This includes overcoming resistance and lack of responses to current immunotherapies.

Using our multi-faceted functional approach, primary human cells and animal models, we are identifying positive and negative regulators of T cells, NK cells, macrophages and myeloid-derived suppressor cells.  Our approach streamlines target validation and IND enabling studies including pharmacology and toxicology, PK/PD and ADA evaluation, tissue cross reactivity assessment, and assay development for patient selection, biomarker analysis and clinical trial monitoring.

Development
We develop products from gene cloning to final drug product focusing on production efficiency and ease of technology transfer and process operations. This “All Stream” approach integrates all aspects of development with the highest level of quality and is designed to improve outcomes by eliminating the traditional “silos” between cell line development, cell culture process development, downstream process development, formulation, analytical chemistry, and product characterization.